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Blood is a specialized bodily fluid that delivers necessary substances to the body’s cells – such as nutrients and oxygen – and transports waste products away from those same cells.

Do you ever wonder what makes up blood? Unless you need to have blood drawn, donate it or have to stop its flow after an injury, you probably don’t think much about it. But blood is the most commonly tested part of the body, and it is truly the river of life. Every cell in the body gets its nutrients from blood. Understanding blood will help you as your doctor explains the results of your blood tests. In addition, you will learn amazing things about this incredible fluid and the cells in it.

Blood is a mixture of two components: cells and plasma. The heart pumps blood through the arteries, capillaries and veins to provide oxygen and nutrients to every cell of the body. The blood also carries away waste products.

The adult human body contains approximately 5 liters (5.3 quarts) of blood; it makes up 7 to 8 percent of a person’s body weight. Approximately 2.75 to 3 liters of blood is plasma and the rest is the cellular portion.

In babies and young children, blood cells are made within the bone marrow (the soft tissue inside our bones) of lots of bones throughout the body. But, as kids get older, blood cells are made mostly in the bone marrow of the vertebrae (the bones of the spine), ribs, pelvis, skull, sternum (the breastbone), and parts of the humerus (the upper arm bone) and femur (the thigh bone).

Blood performs many important functions within the body including:

• Supply of oxygen to tissues (bound to hemoglobin, which is carried in red cells)
• Supply of nutrients such as glucose, amino acids, and fatty acids (dissolved in the blood or bound to plasma proteins (e.g., blood lipids)
• Removal of waste such as carbon dioxide, urea, and lactic acid
• Immunological functions, including circulation of white blood cells, and detection of foreign material by antibodies
• Coagulation, which is one part of the body’s self-repair mechanism (the act of blood clotting when you get cut to stop the bleeding.)
• Messenger functions, including the transport of hormones and the signaling of tissue damage
• Regulation of body pH (the normal pH of blood is in the range of 7.35–7.45)^[3] (covering only 0.1 pH unit)
• Regulation of core body temperature
• Hydraulic functions

In some ways, every person’s blood is the same. But, when analyzed under a microscope, distinct differences are visible. In the early 20th century, an Austrian scientist named Karl Landsteiner classified blood according to those differences. He was awarded the Nobel Prize for his achievements.

Landsteiner observed two distinct chemical molecules present on the surface of the red blood cells. He labeled one molecule “A” and the other molecule “B.” If the red blood cell had only “A” molecules on it, that blood was called type A. If the red blood cell had only “B” molecules on it, that blood was called type B. If the red blood cell had a mixture of both molecules, that blood was called type AB. If the red blood cell had neither molecule, that blood was called type O.

If two different blood types are mixed together, the blood cells may begin to clump together in the blood vessels, causing a potentially fatal situation. Therefore, it is important that blood types be matched before blood transfusions take place. In an emergency, type O blood can be given because it is most likely to be accepted by all blood types. However, there is still a risk involved.

A person with type A blood can donate blood to a person with type A or type AB. A person with type B blood can donate blood to a person with type B or type AB. A person with type AB blood can donate blood to a person with type AB only. A person with type O blood can donate to anyone.

A person with type A blood can receive blood from a person with type A or type O. A person with type B blood can receive blood from a person with type B or type O. A person with type AB blood can receive blood from anyone. A person with type O blood can receive blood from a person with type O.

Because of these patterns, a person with type O blood is said to be a universal donor. A person with type AB blood is said to be a universal receiver. In general, however, it is still best to mix blood of matching types and Rh factors.